Effects of Postnatal Exposure to Mixtures of Non-ortho-PCBs, PCDDs, and PCDFs in Prepubertal Female Rats
Identifieur interne : 002E65 ( Main/Exploration ); précédent : 002E64; suivant : 002E66Effects of Postnatal Exposure to Mixtures of Non-ortho-PCBs, PCDDs, and PCDFs in Prepubertal Female Rats
Auteurs : D. Desaulniers [Canada] ; K. Leingartner [Canada] ; B. Musicki [Canada] ; A. Yagminas [Canada] ; G.-H. Xiao [Canada] ; J. Cole [Canada] ; L. Marro [Canada] ; M. Charbonneau [Canada] ; B. K. Tsang [Canada]Source :
- Toxicological Sciences [ 1096-6080 ] ; 2003-10.
English descriptors
- KwdEn :
Abstract
There are concerns that postnatal exposure to organochlorines present in breast milk could lead to adverse health effects. We reconstituted four mixtures of aryl-hydrocarbon receptor (AhR) agonists (3 non-ortho polychlorinated biphenyls [PCBs], 6 polychlorinated dibenzodioxins [PCDDs], 7 polychlorinated dibenzofurans [PCDFs], or all 16 chemicals together [referred to as AhRM]) based on their concentrations in breast milk, and examined their effects following exposure by gavage from day 1 until day 20 of age. Female neonates received dosages of AhRM equivalent to 1, 10, 100, or 1000 times the amount consumed by an infant over the first 24 days of life. Other groups received the PCBs, the PCDDs, or the PCDFs at the 1000× level. All rats were sacrificed at 21 days of age. Changes in ethoxyresorufin-o-deethylase hepatic activity, thymus and body weights, and serum thyroxin were linked to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalents (TEQ) of the four mixtures (1000×-AhRM > PCDDs > PCBs > PCDFs). To test for AhRM antiestrogenicity, two additional groups received 1.5 μg/kg of 17α-ethynyl estradiol (EE) with or without the 1000×-AhRM. The AhRM had no effect on uterine weight or EE-stimulated uterine growth. The actions of the combined EE and AhRM treatments suggest additive effects in decreasing pentoxyresorufin-o-deethylase activity and spleen weight, but nonadditive/antagonistic effects on adrenal weight and serum thyroxin. In conclusion, (1) 10×-AhRM had no detectable effects, (2) TEQ values relate to observed toxicities, even when testing complex mixtures of AhR agonists, and (3) indications of tissue-specific additive and nonadditive/antagonistic effects, but no synergism, were observed when doses of AhRM were increased, or combined with EE.
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DOI: 10.1093/toxsci/kfg189
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Xiao</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Health Canada, Environmental and Occupational Toxicology Division, Tunney’s Pasture, A.L:0803D, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Cole, J" sort="Cole, J" uniqKey="Cole J" first="J." last="Cole">J. Cole</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Health Canada, Environmental and Occupational Toxicology Division, Tunney’s Pasture, A.L:0803D, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Marro, L" sort="Marro, L" uniqKey="Marro L" first="L." last="Marro">L. 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Tsang</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Reproductive Biology Unit and Division of Reproductive Medicine, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, University of Ottawa; Hormones, Growth and Development Program, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicological Sciences</title><title level="j" type="abbrev">Toxicol. Sci.</title><idno type="ISSN">1096-6080</idno><idno type="eISSN">1096-0929</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-10">2003-10</date><biblScope unit="volume">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="468">468</biblScope><biblScope unit="page" to="480">480</biblScope></imprint><idno type="ISSN">1096-6080</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1096-6080</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CYP 2B</term><term>breast milk</term><term>mixture</term><term>polychlorinated biphenyls</term><term>polychlorinated dibenzodioxins</term><term>polychlorinated dibenzofurans</term><term>prepubertal</term><term>rat</term><term>toxic equivalent</term><term>uterotrophic bioassay</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are concerns that postnatal exposure to organochlorines present in breast milk could lead to adverse health effects. We reconstituted four mixtures of aryl-hydrocarbon receptor (AhR) agonists (3 non-ortho polychlorinated biphenyls [PCBs], 6 polychlorinated dibenzodioxins [PCDDs], 7 polychlorinated dibenzofurans [PCDFs], or all 16 chemicals together [referred to as AhRM]) based on their concentrations in breast milk, and examined their effects following exposure by gavage from day 1 until day 20 of age. Female neonates received dosages of AhRM equivalent to 1, 10, 100, or 1000 times the amount consumed by an infant over the first 24 days of life. Other groups received the PCBs, the PCDDs, or the PCDFs at the 1000× level. All rats were sacrificed at 21 days of age. Changes in ethoxyresorufin-o-deethylase hepatic activity, thymus and body weights, and serum thyroxin were linked to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalents (TEQ) of the four mixtures (1000×-AhRM > PCDDs > PCBs > PCDFs). To test for AhRM antiestrogenicity, two additional groups received 1.5 μg/kg of 17α-ethynyl estradiol (EE) with or without the 1000×-AhRM. The AhRM had no effect on uterine weight or EE-stimulated uterine growth. The actions of the combined EE and AhRM treatments suggest additive effects in decreasing pentoxyresorufin-o-deethylase activity and spleen weight, but nonadditive/antagonistic effects on adrenal weight and serum thyroxin. In conclusion, (1) 10×-AhRM had no detectable effects, (2) TEQ values relate to observed toxicities, even when testing complex mixtures of AhR agonists, and (3) indications of tissue-specific additive and nonadditive/antagonistic effects, but no synergism, were observed when doses of AhRM were increased, or combined with EE.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Desaulniers, D" sort="Desaulniers, D" uniqKey="Desaulniers D" first="D." last="Desaulniers">D. Desaulniers</name></noRegion><name sortKey="Charbonneau, M" sort="Charbonneau, M" uniqKey="Charbonneau M" first="M." last="Charbonneau">M. Charbonneau</name><name sortKey="Cole, J" sort="Cole, J" uniqKey="Cole J" first="J." last="Cole">J. Cole</name><name sortKey="Leingartner, K" sort="Leingartner, K" uniqKey="Leingartner K" first="K." last="Leingartner">K. Leingartner</name><name sortKey="Marro, L" sort="Marro, L" uniqKey="Marro L" first="L." last="Marro">L. Marro</name><name sortKey="Musicki, B" sort="Musicki, B" uniqKey="Musicki B" first="B." last="Musicki">B. Musicki</name><name sortKey="Tsang, B K" sort="Tsang, B K" uniqKey="Tsang B" first="B. K." last="Tsang">B. K. Tsang</name><name sortKey="Xiao, G H" sort="Xiao, G H" uniqKey="Xiao G" first="G.-H." last="Xiao">G.-H. Xiao</name><name sortKey="Yagminas, A" sort="Yagminas, A" uniqKey="Yagminas A" first="A." last="Yagminas">A. Yagminas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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